ABSTRACT
Abstract Pakistan Registry of Intensive Care (PRICE) is a platform that has enabled standardized COVID-19 clinical data collection based on ISARIC/WHO Clinical Characterization Protocol. The near real-time data platform includes epidemiology, severity of illness, microbiology, treatment and outcomes of patients admitted with suspected or laboratory confirmed COVID19 infection to 67 intensive care and high dependency units across the country. Data has been extracted and analysed at regular intervals to inform stakeholders and improve care practices. This is our 28th report including all patients with suspected or confirmed COVID-19 from 26th March 2020 to 26th December 2021. Key findings from 8624 patients who met eligibility criteria, are as follows: [bullet] Median age of 60 years (IQR 50-70). [bullet] The most common symptoms were shortness of breath (n = 6428, 77.8%), fever (n = 6091, 73.8%), and Cough (n = 3354, 38.9%) [bullet] The most common comorbidity was hypertension followed by diabetes. [bullet] During the course of illness 2804 (32.6%) patients received non-invasive ventilation, whereas 2474 (28.8%) patients had mechanical ventilation as their highest organ support. In addition, 2246 (26.1%) patients needed haemodynamic support and 1249 (14.7%) patients required renal replacement therapy as their highest organ support. [bullet] Median APACHE II score was 18 [bullet] Overall mortality at ICU discharge was 39.2% [bullet] Increasing age and requirement for invasive mechanical ventilation were independent risk factors for mortality increased the risk of death
Subject(s)
Dyspnea , Fever , Diabetes Mellitus , Hypertension , Death , COVID-19ABSTRACT
Background: The first case of COVID-19 pneumonia was reported in Pakistan at the end of February 2020. In this single center study we report epidemiology, clinical, laboratory, and radiology findings, treatment and outcome of patients with COVID-19 pneumonia. Methods: This retrospective study was undertaken between 21st March to 15th May 2020 where 6712 persons were screened for exposure and symptoms of COVID-19 and 2715 was test by RT-PCR. In all 317 patients with confirmed COVID-19 were admitted. Data were retrieved from hospital electronic health records and analysis performed using SPSSv.20. Findings: COVID-19 positivity rate in general public was 24·9% and 38.6% in in-patients. A total of 317 patients were admitted in corona wards. Their mean age was 47·1±14·8 and 66·5% were males. Exposure or contact history was given by 43·2%. Median duration of symptoms was six days (IQR 3-8·7) with fever in 75·4%, cough in 59·0% and dyspnea in 59%. Co-morbids were hypertension in 27·1%, diabetes in 27·4%, ischemic heart disease in 6·0%, and 63 (19·9%) had ESRD. Disease was severe in 40·4%of patients with significantly increased inflammatory markers, CRP-H, ferritin, D-Dimer, NLR in 81-97%, bilateral infiltrates and ground glass opacity in 73·9% and complication ARDS in 71%, secondary infection in 24·3%, and multi-organ failure in 8·7%. The overall death rate was 16·1%, 30·4% in severe and 7·9% in non-severe disease. Interpretation: The COVID-19 infected a quarter of the tested population where majority had non-severe disease. Severe disease was associated with old age, high co-morbids and mortality.Funding Statement: This study was funded from institutional resources. RT-PCR Kits for COVID-19 testing and were provided by provincial government.Declaration of Interests: The authors declare no competing interests.Ethics Approval Statement: The study was approved by the Ethical Review Committee of the institute, Ref No: SIUT-ERC 2020/A-217.